New Delhi, Aug 25 (IANS) – Genetic screening of embryos created through IVF could significantly improve the chances of conception for women above 35, helping them have babies in less time, according to a new study.
Researchers at King’s College London, UK, conducted the world’s first randomised controlled trial focusing solely on women aged 35–42, a demographic with a higher likelihood of producing embryos with chromosomal abnormalities.
The trial assessed the use of Preimplantation Genetic Testing for Aneuploidy (PGT-A), which screens embryos for abnormal chromosome numbers before implantation. Women in this age group often face difficulties conceiving and a higher risk of miscarriage due to chromosomal errors.
The findings, published in the Journal of Clinical Medicine, revealed that the PGT-A group had a cumulative live birth rate of 72%, compared to 52% in the control group, after up to three embryo transfers. Moreover, those who underwent PGT-A achieved pregnancy in fewer transfers, shortening the time to conception — a key factor for women of advanced reproductive age.
“With more women starting families after 35, chromosomal abnormalities become a significant hurdle, leading to failed implantations and miscarriages,” said Dr. Yusuf Beebeejaun of King’s College London. “Our research indicates that targeted use of PGT-A can help these women conceive earlier while reducing the emotional strain of multiple failed cycles.”
The pilot study included 100 women undergoing fertility treatment at King’s Fertility, evenly split between the PGT-A and control groups. It aimed to address a key evidence gap and assess the feasibility of larger, multi-centre trials focusing on older patients.
“Further large-scale studies are needed, but improving treatment efficiency and reducing the time to pregnancy could substantially ease the physical and emotional challenges of IVF for women over 35,” added Dr. Sesh Sunkara, the study’s lead author.