The discovery, by QIMR Berghofer Medical Research Institute in Australia, raises exciting new possibilities for screening, preventing and fighting this increasingly prevalent disease.
Treatment options for the cancer are limited, with a hysterectomy often the first line of defence.
“Everyone has testosterone, but our research suggests that women with higher levels of the hormone are at greater risk of developing endometrial cancer,” said Associate Professor Tracy O’Mara, from the Institute.
“In establishing an independent relationship between testosterone and endometrial cancer, the study opens up potential new avenues for treatment.
“We’re really excited by these findings and hope that with further research, we might be able to treat endometrial cancer by targeting or inhibiting testosterone with existing drugs,” O’Mara said.
In the study, published in the journal iScience, the researchers carried out advanced genetic analysis to identify five independent risk factors for endometrial cancer.
These risk factors include body weight, age at onset of menstruation and menopause, and testosterone levels. The testosterone connection was related to a specific region of the human genome which the study discovered has links to a higher risk of endometrial cancer.
“It is very promising to see testosterone levels emerge so strongly as a likely risk factor, because a person’s testosterone can be modified,” O’Mara said.
“There are already approved drugs designed to block and counteract the hormone’s effects. Further research may justify trying to repurpose those drugs to help women with endometrial cancer. “It is really important that we do find more therapeutic options, as the current first line treatment for endometrial cancer is a hysterectomy. This is obviously highly invasive, and affects fertility in younger patients.”
According to Dylan Glubb, Associate Professor, from QIMR said they would use laboratory-grown organoids resembling endometrial cancer tumours, to investigate genes involved in the development of the disease.
“We have identified a significant number of genetic regions linked to endometrial cancer, but we don’t yet know which particular genes are involved. This study allows us to test which genes are important for the growth of the organoids and the endometrial cancer tumours they represent.
“Our ultimate goal is finding new genes which can be targeted to treat endometrial cancer, as we know drugs with a genetic basis are more likely to be effective.”